Scientists warn against easing lockdown amid mutant Covid

Scientists have warned there can be no early easing of lockdown rules after evidence the mutant coronavirus variant which emerged in the south-east of England may be more deadly than the original strain.

UK Prime Minister Boris Johnson said on Friday the new variant may be associated with “a higher degree of mortality”.

He said the UK Government could have to bring in further restrictions on travel following a warning that other new variants found in South Africa and Brazil may be more resistant to the vaccines that have been developed.

Meanwhile, the British Medical Association has reportedly written to chief medical officer for England Professor Chris Whitty calling for the gap between doses of the Pfizer/BioNTech vaccine to be reduced to six weeks.

The private letter, seen by the BBC, said the current plans of people waiting up to 12 weeks for a second dose – which Health Secretary Matt Hancock said is supported by data from an Israeli study – are “difficult to justify”.

It said: “The absence of any international support for the UK’s approach is a cause of deep concern and risks undermining public and the profession’s trust in the vaccination programme.”

At a No 10 news briefing on Friday, the UK Government’s chief scientific adviser Sir Patrick Vallance said early evidence suggested the new UK variant could increase mortality by almost a third in men in their 60s.

His warning followed a briefing by scientists on the Government’s New and Emerging Respiratory Virus Threats Advisory Group (Nervtag) which concluded there was a “realistic possibility” that it was associated with an increased risk of death.

It was already known that the new variant was up to 70% more transmissible than the original – leading to a tightening of restrictions across the UK from late December onwards.

Rowland Kao, professor of veterinary epidemiology and data science at the University of Edinburgh, said the latest findings suggested it was responsible for the “unexpectedly high” numbers of hospital admissions, especially around London.

“While the recent results showing declining case numbers is good news, and suggest that the variant is controllable via existing measures, these results on deaths imply that burden in hospitals will continue to be high requiring a more prolonged period of restrictions,” he said.

Professor Sir Mark Walport, a former government chief scientific adviser and a member of the Scientific Advisory Group for Emergencies (Sage), said even stricter measures may be needed if cases do not continue falling “at pace”.

“Decisions are going to have to be made on the basis of the evidence,” he told BBC News.

“If the evidence shows that the decrease in cases isn’t continuing, then clearly policymakers will have to consider much tougher measures.”

Johnson said the case numbers remained “forbiddingly high” and that it would be a mistake to unlock in England if it were to lead to “another big rebound” in the disease.

On another bleak day, with a further 1,401 deaths across the UK of people who had tested for Covid-19 in the previous 28 days, there was some good news with evidence the various lockdown measures in place across the country were having an effect.

A sub-group of Sage said the reproduction number, the R, for coronavirus had fallen to below one across the UK, suggesting a retreating epidemic.

The Scientific Pandemic Influenza Group on Modelling (Spi-M) put the R, which represents how many people an infected person will pass the virus on to, at 0.8 to 1.0, down from 1.2 to 1.3 the previous week.

It said the number of new infections was shrinking by between 1% and 4% every day.

However, Professor Whitty said the situation across the UK remained “extremely precarious”.

“A very small change and it could start taking off again from an extremely high base,” he said.

“If that happened again, we would be in really, really deep trouble.”

Professor Lawrence Young, a virologist at Warwick Medical School, suggested the more serious concern was the evidence that the South African and Brazilian variants may be less susceptible to the vaccines.

“The other virus variants identified in South Africa and Brazil are more worrying as they carry more changes in the spike protein of the virus,” he said.

“It is important that we now determine the neutralising ability of antibodies against virus variants generated in response to vaccination and study the immune response in individuals infected with virus variants.”

Sir Patrick said the evidence remained uncertain and there was no sign either the South African or Brazilian variants had any “transmission advantages” over those in the UK and so would not be expected to spread more quickly or “take over”.

Meanwhile, a year has passed since the first people in Scotland were tested for coronavirus.

The Scottish Government confirmed on January 23, 2020, that five people were being examined after presenting with symptoms of the illness.

Two of them had been diagnosed with influenza after travelling to Wuhan, China, where the virus originated.

The first confirmed coronavirus patient in Scotland came on March 1, and was from Tayside.

On March 13, the first death related to the virus was recorded.

The UK entered full lockdown for the first time on March 23, but less than a month later Scotland’s chief medical officer Catherine Calderwood resigned after making two trips to her second home.

A route-map out of the coronavirus restrictions was first published by the Scottish Government on May 21.

This has been updated throughout the pandemic and includes rules on school closures, business operations and personal freedoms.

Scotland’s largest city, Glasgow, has seen the highest volumes for coronavirus infections and deaths – more than 31,700 and 863 respectively.

There have been almost 170,000 positive Covid-19 cases and 5,628 related deaths north of the border, as of Friday.

Scottish Government figures show 358,454 people have received the first dose of the Covid vaccination, and 4,689 have received the second dose