The A76 was blocked after a rush hour crash amid widespread fog on Tuesday morning.
Emergency services were called to the scene near Kilmarnock at 7.45am.
Transport Scotland confirmed the road is currently blocked at the Bellfield Interchange.
A crash left an overturned vehicle blocking the A725 Bellziehill.
Drivers were advised to plan ahead before making their journey.
Yesterday vs. Today š±
— Traffic Scotland (@trafficscotland) October 17, 2023
If our visibility is reduced, then so is yours.
ā¹ļø If it's not safe to continue on your journey, safely pull in, park and keep your hazard lights on – but turn off your headlights.
š How to drive safely in fog: https://t.co/11KpuHKsK4 pic.twitter.com/lgsXxxoBLl
The crash comes as parts of Scotland awoke to thick fog on Tuesday morning.
Transport Scotland warned drivers to “safely pull in” and park with their hazards on should their visibility become too poor to continue their journey.
ScotRail warned commuters to take care at railway stations on Tuesday morning.
“We’re doing our best to make sure platforms are gritted, but they might still be slippy,” a spokesperson said.
It was a chilly night last night and the hills above the #A83 above Glen Kinglas are looking stunning.
— BEAR NW Trunk Roads (@NWTrunkRoads) October 17, 2023
We were out gritting overnight, but take care on your morning commute.#DriveSafe #ReadyforWinter pic.twitter.com/ks1gzVBuGw
It comes as Storm Babet is set to batter Scotland with heavy rain and strong winds from Wednesday.
The second named storm of the season is expected to cause widespread flooding and disruption this week as many areas are still recovering from severe weather earlier this month.
Follow STV News on WhatsApp
Scan the QR code on your mobile device for all the latest news from around the country