Drivers faced an almost 55-mile diversion after the A82 was closed in both directions following a crash near Tyndrum.
Emergency services were alerted to the crash around 11am on Saturday morning.
Due to the location of the crash, a 54.4 mile diversion was put in place for motorists, who have been warned to expect delays to their journey.
Around 1pm, Traffic Scotland confirmed the road had been cleared and the A82 was open as normal.
Police Scotland has been contacted for comment.
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