Keir Starmer will face questions in Parliament before MPs vote on the assisted dying bill.
The Prime Minister will take questions from the leader of the opposition, Kemi Badenoch, with the Bill likely to be on the agenda.
Labour MP Kim Leadbeater formally introduced her Bill to give choice at the end of life for the terminally ill in October.
A debate and first vote are expected to take place on November 29.
If the Bill passes the first stage in the Commons, it will go to committee stage where MPs can table amendments, before facing further scrutiny and votes in both the House of Commons and the House of Lords, meaning any change in the law would not be agreed until next year at the earliest.
Starmer is also expected to make comments on a ceasefire deal between Israel and Hezbollah, which came into effect at 2am this morning.
He has described the agreement as “long overdue”.
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